Nkosazana Clarice Dlamini-Zuma (née Dlamini; born 27 January 1949), sometimes referred to by her initials NDZ, is a South African politician, medical doctor and former anti-apartheid activist. A longstanding member of the African National Congress (ANC), she currently serves as Minister in the Presidency for Women, Youth and Persons with Disabilities and is the Chancellor of the University of Limpopo.

Dlamini-Zuma was born and educated in the former Natal province, where, as a student, she became involved in the Black Consciousness Movement through the South African Students' Organisation. Between 1976 and 1990, she lived in exile outside South Africa, primarily in the United Kingdom and Swaziland, where she practiced medicine and engaged in ANC activism. Since 1994, Dlamini-Zuma has served in the cabinet of every post-apartheid South African president. She was Minister of Health under President Nelson Mandela, and Minister of Foreign Affairs for ten years under Presidents Thabo Mbeki and President Kgalema Motlanthe. During the first term of President Jacob Zuma, she was Minister of Home Affairs, in which portfolio she was credited with turning around a dysfunctional department. She was absent from the South African government between October 2012 and January 2017, when she served as the Chairperson of the African Union Commission, making her the first woman to lead either that organisation or its predecessor, the Organisation of African Unity.

She has been a member of the ANC's National Executive Committee since the early 1990s, and has twice campaigned unsuccessfully for leadership positions in the party: in 2007, at the ANC's 52nd National Conference, Motlanthe defeated her to win the deputy presidency; while at the 54th National Conference in 2017, she narrowly lost the ANC presidency to Ramaphosa, the current incumbent.